Epidermal growth factor (EGF), heparin-binding epidermal growth factor (HB-EGF), platelet-derived growth factor (PDGF), insulin-like growth factor (IGF), transforming growth factor-alfa (TGF-α), transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), acidic fibroblast growth factor (acidic-FGF), basic fibroblast growth factor (basic-FGF), activin and myostatin are the most important growth factors that mediate the estrogens and progesterone action within the uterine leiomyoma physiology [54,80,82,83,84]. This evidence concerns the gene TGFB1 and Uterine leiomyoma.