In particular, the macrophage (CD68 positive cells) density is significantly higher in the endometrium close to the leiomyoma nodules compared to the autologous endometrium far from the leiomyoma, as well as compared to the allogenic endometrium of women without uterine fibroids in the mid-to-late secretory phase [148]. This evidence concerns the gene CD68 and uterine corpus leiomyoma.