SNCA and Parkinson disease: Chemical enhancement of Chaperone Mediated autophagy (CMA) protected PD astrocytes and vmDAns via clearance of α-synuclein accumulations. Non-cell autonomous contribution of astrocytes during PD pathogenesis. Possibility of exploring a therapeutic strategy of blocking pathogenic cross talk between neurons and glial cells. Dysfunctional CMA (chaperone mediated autophagy), impaired macroautophagy, progressive α-synuclein accumulation.