3 skin fibroblast groups -1) Control (Patients who did not develop PD)2) Idiopathic PD—IPD (Patients without G2019S PD)3) G2019S PD patients The overall goal of the study is to examine variation in the levels of histone acetyltransferase (HAT) and histone deacetylase (HDAC), described as the key players of autophagy. The gene discussed is TMPRSS11D; the disease is Parkinson disease.