The identification of such precursor lesions may have clinical implications, requiring specific endoscopic surveillance programs on the bases of their malignant potential [5] or screening of remaining organs and family members, when they are associated with hereditary tumor syndromes, such as familial adenomatous polyposis 1 (FAP), MUTYH-associated polyposis (MAP) or multiple endocrine neoplasia 1 syndrome (MEN1). Here, FAP is linked to mutyh-associated polyposis.