CAFs acquire myofibroblast properties which contribute to diseased tissue remodeling and express markers to sustain cell proliferation and tumor growth: Such as fibroblast specific protein 1 (FSP-1), fibroblast activation protein-alpha (FAP-α), α-smooth muscle actin (α-SMA) and platelet-derived growth factor receptor (PDGFR). The gene discussed is PDGFRB; the disease is neoplasm.