PTGS2 and neoplasm: The therapeutic combination of T + C strongly inhibited COX-2 expression compared to the control group (mean difference 0.02827, 95% CI 0.02574 to 0.03080, p < 0.0001) and trametinib used alone (mean difference 0.02884, 95% CI 0.02631 to 0.03137, p < 0.0001), managing to reduce tumor-associated inflammation.