Celecoxib’s main chemopreventive capabilities that could be used in melanoma include: Inhibition of proliferation and induction of apoptosis through death receptor (caspase-8/caspase-3 activation) and mitochondrial pathways (caspase-9 activation), inhibition of angiogenesis, invasion and prevention of melanoma cell immune escape [33,34,35]. Here, CASP9 is linked to melanoma.