Figure 1 showed change in BW (ΔBW), in LSM (ΔLSM), according to PNPLA3 and HSD17B13 polymorphism. The PNPLA3 genotype was associated with a greater reduction rate of BW (CC: 2.9%, CG: 1.3%, GG: 0.2%) (p = 0.035). HSD17B13 polymorphism had no impact on ΔBW (p = 0.687). The ΔLSM was not associated with both PNPLA3 and HSD17B13 polymorphism (p = 0.439, p = 0.608, respectively). The ΔLSM had no difference in each fibrosis stage, in both PNPLA3 and HSD17B13 polymorphisms. This evidence concerns the gene PNPLA3 and fibrosis.