KLF4 and sialidosis: To generate sialidosis-specific iPSC models, fibroblasts from two sialidosis patients with different mutations [p.G227R and p.V275A/R347Q] in the NEU1 gene were reprogrammed into iPSCs using Sendai virus (SeV) vectors encoding for OCT4, SOX2, KLF4, and C-MYC (Figure 1A).