CDKN2A and melanoma: For instance, the most recurrent ones in chronic sun-induced damage (CSD) and non-CSD melanoma affect genes in key signaling pathways involved in proliferation (BRAF, NRAS and NF1), growth and metabolism (PTEN and KIT), cell identity (AT-rich interaction domain 2 (ARID2)), resistance to apoptosis (TP53), cell cycle control (cyclin-dependent kinase inhibitor 2A (CDKN2A), and replicative lifespan (telomerase reverse transcriptase (TERT)) [5].