BMP2 and osteoporosis: Finally, the peptide MPDW isolated from Nannochloropsis oculata showed interesting anti-osteoporosis activity by promoting osteoblast differentiation, increasing expression of several osteoblast phenotype markers (e.g., alkaline phosphatase ALP, osteocalcin, collagen type I, BMP-2, BMP2/4) and bone mineralization in both human osteoblastic cells (MG-63) and murine mesenchymal stem cells (D1) [185].