CASP8 and breast carcinoma: For example, an EPA-enriched fraction from the diatom Cocconeis scutellum Ehrenberg (Bacillariophyceae) had antiproliferative activity on breast carcinoma (BT20) cells [127], with activation of caspase-3 and caspase-8, and cell cycle progression block from S to G2-M phases [127].