A previous study demonstrated that the CXCL16 signaling pathway contributes to the renal injury in diabetic nephropathy mouse model [66] and CXCR6 regulates the collagen deposition and expression of collagen I and fibronectin through recruitment of bone marrow derived fibroblast in renal fibrosis [67]. The gene discussed is CXCR6; the disease is diabetic kidney disease.