In Pompe disease (PD), serum biomarkers of tissue damage such as creatine kinase (CK), creatine kinase-muscle/brain (CK-MB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) are usually used in laboratory tests, but they are nonspecific and have limited prognostic value. This evidence concerns the gene GPT and glycogen storage disease II.