NFKB1 and cancer: Moreover, SIRT1 inactivates NF-κB, a transcription factor that regulates inflammation and promotes inflammation-associated cancer [30], by deacetylating the K310 residue of the NF-κB p65 subunit, as was found in human cell lines from non-small-cell lung cancer, immortalized lung epithelium [31], and normal gastric epithelium [32].