The translational relevance of these observations is underscored by neuroradiological studies showing that the intravenous administration of recombinant tPA to acute ischemic stroke patients also increases the permeability of the blood–brain barrier [88] which is in line with a reported 10-fold increase in the risk of hemorrhagic complications in recombinant tPA (rtPA)-treated stroke patients [75]. Here, PLAT is linked to stroke disorder.