PLAT and Stroke: This discrepancy was dramatically brought to the forefront of the scientific discussion by the publication of a National Institute of Neurological Disorders and Stroke (NINDS)-led clinical study showing that treatment with recombinant tPA within 3 h of the onset of symptoms was associated with complete or nearly complete recovery in neurological function in a significant number of acute ischemic stroke patients [75,109], and by the subsequent incorporation of rtPA in the protocols used for the treatment of these patients [110].