EHD3 hypermethylation was observed in most Western alimentary canal cancers compared with paired adjacent normal tissues (Figure 1C), such as colon cancer (68.4%, 26/38), esophageal cancer (60.0%, 9/15), liver cancer (33.3%, 4/12), gastric cancer (2/2, 100%), pancreatic cancer (10.0%, 1/10), and rectal cancer (42.9%, 3/7). This evidence concerns the gene EHD3 and esophageal cancer.