METTL14 and acute myeloid leukemia: However, paradoxically, METTL14 was reported to be highly expressed in normal hematopoietic stem/progenitor cells (HSPCs) and AML with t (11q23), t (15;17), or t (8;21) and necessary for development and maintenance of AML and self-renewal of leukemia stem/initiation cells (LSCs/LICs) [347].