METTL3 upregulation increases translation of MYC, BCL2 and PTEN mRNAs in acute myeloid leukemia (AML), and METTL3 loss leads to increased levels of phosphorylated AKT, promoting differentiation of hematopoietic stem/progenitor cells (HSPCs) [332] (Table 2). The gene discussed is PTEN; the disease is acute myeloid leukemia.