Another widely used anthracycline in the treatment in a broad spectrum of cancers like breast, esophageal carcinomas, endometrial carcinomas, bile duct, pancreatic, gastric, liver, Hodgins and non-Hodgins lymphoma, osteosarcoma, Kaposi’s sarcoma, and soft tissue sarcomas is Doxorubicin [183,184] which works by increasing production of ROS resulting in the activation of the tumor suppressor p53 and ultimately tumor cell death [185,186,187]. This evidence concerns the gene TP53 and cancer.