Both natural lipophilic polyphenols and omega-3 PUFAs are well-known suppressors of the Wnt- and NF-κB-related pathways, at least, individually, and often have been targeted in colon cancer research, because the majority of colon tumors are driven by aberrant Wnt signaling in intestinal stem cells [90]. Here, NFKB1 is linked to colonic neoplasm.