In a sub-analysis of the I-PRESERVE trial, the following variables were associated to a ≥10% risk of SCD over 5 years at multivariable analysis: age, gender (male), history of diabetes mellitus, history of myocardial infarction, left bundle branch block (LBBB) and loge NT-proBNP [56]; however, to date there is no trial demonstrating a benefit of ICD in the HFpEF population. This evidence concerns the gene NPPB and Schnyder corneal dystrophy.