Similar results were obtained by a sub-analysis of the TOPCAT trial [54], after accounting for competing risks of non-SCD: only male sex and insulin-treated diabetes mellitus identified patients at higher risk for SCD, although with modest discrimination (C-statistic = 0.65); age, LVEF, CAD, LBBB and baseline therapies were not independently associated with SCD. This evidence concerns the gene INS and Schnyder corneal dystrophy.