RBPJ and cancer: Then, NICD converts the CBF1-Su(H)-LAG1 (CSL) repressor complex into a transcriptional activator complex, driving the transcription of several target genes, including cyclin D1, Myc, Bcl-2, Hes1, and Hey1, involved in cancer cell cycle progression, as well as the inhibition of apoptosis and metastasis formation.