Particularly, the upstream regulator IRF7 genes (Figure 3b) consists of 33 dataset genes downstream of regulators and 13 other regulators in the network (IRF3, IFNA1/IFNA13, IFN-α and IFNA2 directly connected to IRF7, whereas STAT4, STAT1, STAT3, STAT2, IRF1, MYC (Myc proto-oncogene protein), PML (promyelocytic leukemia) and STAT6 genes are indirectly connected). The gene discussed is IRF7; the disease is acute promyelocytic leukemia.