IFNA1 and cancer: On this regard, IFN based therapies may not be successful at eradicating all cancer cells and those cells that survive frequently arise with more aggressive features; for instance, radiosensitive squamous cell carcinoma (SCC) xenograft becomes resistance after repetitive doses of radiation [57,58,59,60] and repetitive doses of type I IFN confers cell resistance to X-rays [61].