STAT1 and cancer: Therefore, it suggests that targeting or suppressing these IRDS genes in cancer could benefit in increasing the (chemo- and radiotherapy) sensitivity, and few studies are already been performed in this direction: (i) STAT1 is proposed as the main driver of the IRDS expression and resistance, and its overexpression in a SCC cell line conferred resistance to irradiation, whereas its suppression resulted in increased sensitivity [85].