The CXCL1 (C-X-C motif chemokine ligand 1) and CXCL10, ligands for chemokine receptor 2 (CXCR2) and chemokine receptor 3 (CXCR3), respectively, are the only members of CXC chemokines family identified as IRDS genes and have been implicated in cancer progression and metastasis. Here, CXCL1 is linked to cancer.