Safety and tolerability of sacubitril/valsartan in pediatric patients were consistent with that observed in adult patients.” The effect of inhibition of neprilysin on the level of NT-proBNP is minimal as it is cleared from the circulation mainly by neuropeptide receptors [51], making this a valuable biomarker to measure and track, as a decrease in NT-proBNP may then be attributable to improved HF and not a drug effect. The gene discussed is NPPB; the disease is hydrops fetalis.