MCAM and melanoma: The same group led by Lara Prosen used the SPIONs-PAA-PEI complex to deliver plasmid DNA encoding short hairpin RNA against MCAM (the melanoma cell adhesion molecule) to explore the antitumor and antiangiogenic effects in vivo on melanoma tumors in mice [89], and to explore the distribution, accumulation, uptake, and the consequent therapeutic effect [90].