Consistent with the essential roles of ClpXP in maintaining OXPHOS function, expression of ClpP has also increased in acute myeloid leukemia [24], as well as some patients with solid tumors such as breast, lung, liver, ovary, bladder, prostate, uterus, stomach, prostate, testis, thyroid and non-small cell lung cancer (NSCLC) [26,27,29]. Here, CLPP is linked to non-small cell lung carcinoma.