To identify the molecular pathways leading to PSMB8-AS1 induction in SSc, its expression was assessed in healthy human monocytes cultured for 2, 5, and 18 h in the presence of LPS (TLR4 ligand), R848 (TLR7/8 ligand), IFNα, and TGFβ, all stimuli linked to monocyte activation and fibrosis in SSc [32,33,34,35]. This evidence concerns the gene TLR4 and systemic sclerosis.