Interestingly, several studies have reported that either UHRF1 downregulation or targeting its functional domains can act as a trigger that reactivates several TSGs and enables cancer cells to undergo apoptosis, highlighting UHRF1 as a promising target for cancer drug development [23,24,25,26,27,28,29,30,31,32,33,34,35]. Here, UHRF1 is linked to cancer.