Through these coordinated interactions, UHRF1 ensures a strong crosstalk between DNA methylation and histone post-transcriptional modifications (especially histone deacetylation and methylation), thereby silencing several TSGs, such as p16INK4A, hMLH1 and BRCA1, throughout successive cell divisions, and facilitating the successful inheritance of the cancer phenotype by the daughter cells [5,11,12]. The gene discussed is UHRF1; the disease is cancer.