In human astrocytoma cells and Jurkat cells, TQ was shown to induce a concentration- and time-dependent degradation of UHRF1 and α/β tubulin, while no similar effect was observed in normal human fibroblast cells, again suggesting that TQ exerts a selective effect on UHRF1 [52]. This evidence concerns the gene UHRF1 and astrocytoma (excluding glioblastoma).