Interestingly, the depletion of UHRF1, but not of its partner HAUSP, significantly increased the expression of the HHIP and IGFBP3 genes and decreased the H3K9me2 mark at the HHIP and IGFBP3 TSG loci, leading to the inhibition of hepatoblastoma cell growth [130]. The gene discussed is UHRF1; the disease is hepatoblastoma.