We further assessed the relationship of age groups with tumor LINE-1 hypomethylation, controlling for lifestyle and clinical factors as well as other tumor molecular characteristics (microsatellite instability (MSI) status, CpG island methylator phenotype (CIMP), KRAS mutation, BRAF mutation, and PIK3CA mutation) in multivariate-adjusted linear regression analysis. This evidence concerns the gene BRAF and neoplasm.