SIRT1 and obesity due to melanocortin 4 receptor deficiency: Resveratrol may affect the activity of various intracellular targets such as adenosine monophosphate-activated protein kinase (AMPK), the deacetylating enzyme sirtuin-1 (SIRT-1), and the peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), all altered in the metabolic abnormalities present in patients with obesity [12,13].