Hu et al. demonstrated that the lncRNA ST3GAL6 antisense 1 (ST3GAL6-AS1), which derives from the promoter region of ST3GAL6, recruits histone methyltransferase MLL1 to the promoter region of ST3GAL6, inducing activation of ST3GAL6 transcription, and consequent inhibition of the PI3K/AKT signaling in colorectal cancer (CRC) cell lines. The gene discussed is ST3GAL6; the disease is colorectal cancer.