Conversely, the same group found that ST8SIA4 was downregulated in highly invasive follicular thyroid carcinoma (FTC) cells and tissues, and that ST8SIA4 inhibited migration and invasion of (FTC) cells both in vitro and in vivo, suggesting that ST8SIA4 downregulation may contribute to FTC progression [35]. This evidence concerns the gene ST8SIA4 and thyroid cancer, nonmedullary, 2.