Suppression of ST3GAL5 or ST8SIA4 overexpression regulate the activity of PI3K/Akt signaling and increase the expression P-glycoprotein (P-gp) and MDR-related protein 1 (MRP1) in HL60 cells, contributing to the development of MDR in AML cells [117]. This evidence concerns the gene ST3GAL5 and acute myeloid leukemia.