In the ST6GALNAC family, overexpression of ST6GALNAC1 was shown to induce sTn expression and to confer resistance to cisplatin or 5-fluorouracil (5-FU) in MKN45 gastric cancer cells, whereas its knockdown restored galectin-3-binding sites and sensitized tumor cell to drug-induced cell death [119]. This evidence concerns the gene LGALS3 and neoplasm.