Accordingly, reduction of sialic acid on the murine B16 melanoma cells by knocking down the sialic acid transporter Slc35A1 has shown to reduce the presence of α2,6-linked sialic acids on the cell surface, to enhance effector T cell response and to increase influx and activity of natural killer (NK) cells, reinforcing anti-tumor immunity and curtailing tumor growth [82]. Here, SLC35A1 is linked to neoplasm.