In order to determine the role of SNP genes NOSs in herniation of the lumbar intervertebral disk in humans, a case-control study was carried out with the participation of 179 adult individuals, according to the results of which SNP NOS3 rs2070744 (−786 T/C) and NOS2 rs1060826 (22 G/A) were more common among the control group than in patients with symptoms of hernia of the lumbar intervertebral disk, including those with pain syndrome, which indicates their possible protective role against hernia of the lumbar intervertebral disk. This evidence concerns the gene NOS3 and Hernia.