This correlation was still strong when just comparing among NRAS mutant cell lines (r2 = 0.95, p = 0.024) Similarly, a significant correlation between the levels of CYR61 mRNA levels and resistance to trametinib (AUC) was observed for all melanoma lines (r2 = 0.92, p = 0.012) and for all NRAS mutant lines (r2 = 0.74, p = 0.0003) (Figure 2D). Here, CCN1 is linked to melanoma.