Knockdown of circRNA_0084043 remarkably reduced oxidative stress as evidenced by the down-regulated MDA content, enhanced activities of SOD and GPx via sponging of miR-140-3p and regulation of transforming growth factor alpha (TGFA) in a hyperglycemia-induced human retinal pigment epithelial cell, ARPE-19 [136]. Here, TGFA is linked to Hyperglycemia.