NKX6-1 and diabetes mellitus: Interestingly, many of these transcription factors (PDX1, PAX6, NKX6.1, and NKX2.2) have been shown to be regulated by long noncoding RNAs (lncRNAs) that are differentially expressed in animal models of diabetes or/and in pancreatic islets from T2D donors [110,111,112,113].