Interestingly, α-cell-derived bihormonal INS+/GCG+ cells detected in T1D islets lack DNMT1 and ARX [61], suggesting that similar to murine islets, ⍺- to β-cell transdifferentiation can also be stimulated in human islets by DNMT1 and ARX depletion. Here, ARX is linked to type 1 diabetes mellitus.