Agonistic activation of the ligand-dependent nuclear receptor LRH-1 (liver receptor homolog-1, also termed NR5A2) by the small molecule BL001 [81] in human islets in culture prevented cytokine- and STZ-induced cell death and improved survival and glucose-stimulated insulin secretion in T2D islets [82]. The gene discussed is INS; the disease is type 2 diabetes mellitus.