These findings suggest that the c.724-8G allele of the BBS1 gene, c.196G of the BDNF gene, c.2512A of the BBS14/CEP290 gene, c.745C of the IGF2R gene and c.84T of the SLC6A14 gene constitute potential risk alleles for obesity. This evidence concerns the gene BBS1 and obesity due to melanocortin 4 receptor deficiency.