TP53 and non-small cell lung carcinoma: However, its role in carcinogenesis is different according to the various types of tumors: in CRC, it is considered an oncogene and is involved in Wnt/β-catenin pathway regulation [81]; in HCC, it inhibits p53 expression and p53-target genes [82]; and in NSCLC, it regulates miR-101-3p/SOX9/Wnt/β-catenin axis [83].