It follows that with the present meta-analysis, systematic review and meta-regression, we were able to show that inflammatory markers, here hs-CRP and CRP, are increased in individuals with OSA, though, the pattern of results is not straightforward and uniform; rather, hs-CRP and CRP levels might be higher compared to, or equal to hs-CRP and CRP levels of healthy controls, depending of the blood samples (serum vs. plasma), age (children vs. adults), ethnicity, BMI, sample size and AHI-cut-off values. The gene discussed is CRP; the disease is obstructive sleep apnea syndrome.