TET2-driven CHIP, as well as MDS, is actually characterized by TET2 loss-of-function rather than TET2 protein deletion, and in order to compare these differences, Ito’s group created mice carrying a mutation specifically in the catalytic domain (C terminal) of TET2 and compared these mice to the TET2 KO mice. Here, STUB1 is linked to myelodysplastic syndrome.