The most common RNA-splicing genes mutated in MDS are SF3B1, SRSF2 and U2-complex auxiliary factor 1 (U2AF1); and zinc finger CCCH-type RNA binding motif and serine/arginine-rich 2 (ZRSR2) [12,23,40,41]. Here, SRSF2 is linked to myelodysplastic syndrome.