STUB1 and myelodysplastic syndrome: While it is well-known that CVD is accelerated by metabolic disorders such as diabetes and obesity [118,119,120], as well as autoimmune diseases such as rheumatoid arthritis [121], there is emerging evidence that CHIP-related mutations found in MDS also contribute to heightened CVD in patients with myeloid neoplasms such as MDS [3,122,123].