After uploading the LAGE-1 co-expression genes list from the METABRIC and TCGA datasets into MetaCore program, we discovered that immune and adhesion-related pathway play critical roles in breast cancer development such as “Role of tumor-infiltrating B cells in anti-tumor immunity”, “Cell adhesion_Gap junctions”, “Inhibition of remyelination in multiple sclerosis: regulation of cytoskeleton proteins“, “Cell adhesion_Tight junctions“, “Immune response _CCR3 signaling in eosinophils” (Figure 4). The gene discussed is CTAG2; the disease is breast cancer.