Again, we set the input of MetaCore by the LAGE2A co-expression gene from the METABRIC and TCGA database, and we observed that stemness related pathway play critical roles in breast cancer development such as “Development_Negative regulation of WNT/Beta-catenin signaling in the nucleus”, “Development_Negative regulation of STK3/4 (Hippo) pathway and positive regulation of YAP/TAZ function”, and “Development_Role of growth factors in the maintenance of embryonic stem cell pluripotency”. The gene discussed is STK3; the disease is breast cancer.