We detected highly significant levels of serum piR-823 expression associated with advanced clinical stages of CRC (III and IV) (7.5± 1.5) (p < 0.001), poor differentiation (9.2 ± 1.9) (p < 0.001), and lymph node metastasis (6.8 ± 2.4) (p < 0.05) (Table 3). The gene discussed is PIR; the disease is metastatic malignant neoplasm in the lymph nodes.