Optimizing insulin sensitivity by eating a low-glycemic index diet throughout the life course may help to prevent cerebral hyperinsulinemia and competition of Aβ degradation by insulin, prevent GSK3β hyperactivity and tau hyperphosphorylation [63], and avoid exacerbating the potential effects of ApoE4 protein on the insulin cascade. The gene discussed is MAPT; the disease is Hyperinsulinemia.