However, 5hmC strongly persisted on oncogenic genes such as CCND1, CCND2, and MMSET, as well as at enhancers of CCND2 and MYC. The potential value of 5hmC as a prognostic marker was underscored by a recent study of circulating cell-free DNA from 184 newly diagnosed MM patients, in which 5hmC was mapped across an eight-gene panel and correlated with overall survival in the MM patients [107]. This evidence concerns the gene CCND2 and Miyoshi myopathy.