As shown in Figure 3d, in addition to OV, the high alteration frequency of the CREB1 gene was also found in pancreatic adenocarcinoma (PAAD), esophageal carcinoma (ESCA), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), and breast invasive carcinoma (BRCA). The gene discussed is CREB1; the disease is invasive breast carcinoma.