Moreover, fluorescence microscopy studies revealed that a significant percentage of CRC-SCs cotreated either with CHK1+RAD51 inhibitors or with CHK1+MRE11 inhibitors displayed a diffuse γH2AX nuclear staining instead of classical nuclear foci, covering either all or a portion of the nuclei (Figure 2C). This evidence concerns the gene MRE11 and colorectal carcinoma.