Additionally, the positive feedback loop between tumor-antigen binding CAR-T produced inflammatory cytokines (e.g., TNF-α, IFN-γ) and subsequently activated bystander immune cell (e.g., macrophages and endothelial cells) released proinflammatory cytokines (e.g., IL-1 and IL-6) is considered as the main mechanism of CRS occurrence [76]. Here, TNF is linked to neoplasm.