EPS8 and leukemia: For DC vaccines, Wu et al. designed an Eps8-DC vaccine by pulsing DCs with EGFR pathway substrate 8-derived peptides and found that Eps8-DCs could effectively facilitate the in vitro expansion of CAR-T cells, with an increased central memory T cell proportion and a decreased effector memory T cell proportion, and boost CAR-T function in relapsed leukemia models [60].