IFNG and neoplasm: Given the hypothesis that chemotherapeutic agents can stimulate tumor cells to produce T cell-attracting chemokines, Hu et al. tested different agents and found that doxorubicin could promote CXCL9/CXCL10 (produced by tumor cells)-mediated T cell penetration in the TME and that IL-12 induced high interferon (IFN)-γ expression synergistically induced chemokine production [53].