Many investigators, including the CATT (Comparison of Age-related Macular Degeneration Treatments) and IVAN (Inhibition of VEGF in Age-related choroidal Neovascularisation) research groups, did not find any significant association between genes polymorphism and visual or anatomic responses to treatment [13,14,15,16,17]. This evidence concerns the gene VEGFA and age-related macular degeneration.