SERPINE1 and polycystic ovary syndrome: Furthermore, Thomson et al. [28] compared the effect of diet, diet combined with the similar volume of aerobic or aerobic-resistance exercises on endothelial function in overweight or obese women with polycystic ovary syndrome and showed a decrease of PAI-1 and sVCAM-1 levels with weight loss in all groups and no change in ADMA levels.