TNF and diabetes mellitus: Giannopoulou et al. [73] observed that 14-week aerobic exercises decreased CRP and IL-6 levels but did not change TNF-α concentrations in obese postmenopausal women with type 2 diabetes, while Jorge et al. [74] noted a decrease in CRP levels in aerobic, resistance, and combined groups (all training on the same volume), and no statistically significant increase in TNF-α and IL-6 levels after 12-week resistance training in subjects with type 2 diabetes mellitus.