Since the first use of NSC-34 cells (a mouse neural hybrid cell line produced by a fusion of motor neuron-enriched embryonic mouse spinal cord neurons with mouse neuroblastoma cells [74]) stably transfected with a vector expressing a human wild type or G93A mutant SOD1 [75,76,77,78,79], several works have continued to prove the resemblance of NSC-34 with motor neurons and their reliability as a cellular model of ALS. Here, SOD1 is linked to amyotrophic lateral sclerosis.