The SLCO1C1 rs3794271 (G > A, C) and PDE3A rs11045392 (T > A, C) polymorphisms are in linkage disequilibrium and have been evaluated in a study with 130 Spanish patients diagnosed with moderate-to-severe psoriasis and treated with anti-TNF medication (n = 130) [88]. The gene discussed is TNF; the disease is psoriasis.