The TNF-308 rs1800629 (A > G), TNF-238 rs361525 (G > A), and TNF-857 rs1799724 (C > T) polymorphisms have been associated with the risk of suffering from psoriasis and with response to anti-TNF drugs in autoimmune pathologies, mainly ankylosing spondylitis, inflammatory bowel disease, psoriatic arthritis and psoriasis [20,46,64]. Here, TNF is linked to ankylosing spondylitis.