Furthermore, polymorphisms of the following genes have shown an association with response to UTK: IL12B (rs3213094), TNFAIP3 (rs610604), LY96 (rs11465996), TIRAP (rs8177374) and TLR5 (rs5744174), and the IL1B rs1143623 and rs1143627 and IL17F rs763780 polymorphisms have proved to be associated with susceptibility to developing toxicity and paradoxical psoriasis due to anti-TNF drugs. This evidence concerns the gene TIRAP and psoriasis.