In addition, depletion of NK cells upon EBV infection of humanized mice favors EBV-associated tumorigenesis and exacerbates infectious mononucleosis (IM) [12,13], a self-limiting disorder characterized by extensive proliferation of polyclonal EBV-specific CD8+ T cells in response to primary EBV infection. The gene discussed is CD8A; the disease is Epstein-Barr virus infection.