Thus, upon activation, NK cells release cytotoxic granules containing perforin and granzymes to directly lyse tumor cells, in a similar fashion to activated cytotoxic T cells, or indirectly by antibody-dependent cellular cytotoxicity (ADCC), triggered through binding of the FcγRIIIA receptor (CD16) on NK cells by the Fc fragment of IgG antibodies. The gene discussed is FCGR3A; the disease is neoplasm.