Treatment with AChE inhibitors to inhibit brain AChE reduces the production of IL-1β in both the hippocampus and blood, showing that cholinergic improvement suppresses both central and peripheral inflammation via α7 nAChR, suggesting that the brain’s cholinergic networks communicate with the anti-inflammatory pathway thereby suppressing peripheral inflammation and play a critical role in the protection against the development of neurodegenerative diseases [129]. Here, CHRNA7 is linked to neurodegenerative disease.