In the Hyper + ischemia group, HO-1 immunoreactivity was significantly increased from 6 h after ischemia, and the immunoreactivity at each point in time was higher than that in the Normo + ischemia group, showing that the ROD was 166.2% at 12 h, 260.4% at 1 day, 280.7% at 2 days, and 275.8% at 5 days after ischemia compared with that in Normo + ischemia group (Figure 2Bb–f,C). Here, HMOX1 is linked to ischemia.