In the Hyper + ischemia group, strong HO-1 immunoreactivity was shown in SP at 6 h, 12 h and 1 day after ischemia, and in all layers at 2 days and 5 days after ischemia, showing that the ROD was 164.0% at 6 h, 188.3% at 12 h, 209.8% at 1 day, 211.6% at 2 days, and 219.1% at 5 days after ischemia compared with that in the Normo + ischemia group (Figure 3Bb–f,C). This evidence concerns the gene HMOX1 and ischemia.