In the Hyper + ischemia group, the expression level of HO-1 significantly and gradually increased until 2 days after ischemia, showing that the level at each point in time was higher (124.8% at 6 h, 157.4% at 12 h, 176.1% at 1 day, and 169.6% at 2 days) than that in the Normo + ischemia group (Figure 1A,B). The gene discussed is HMOX1; the disease is ischemia.