In the Hyper + ischemia group, the expression level of HO-1 was significantly elevated from 6 h after ischemia, and higher (130.4% at 6 h, 130.0% at 12 h, 120.5%1 at 1 day, 116.4% at 2 days, and 105.7% at 5 days) than that in the Normo + ischemia group (Figure 1C,D). This evidence concerns the gene HMOX1 and ischemia.