IGF1R and colorectal carcinoma: Briefly, lower expression of miR-139-5p in CRC induces apoptosis, concomitantly with upregulation of apoptosis-related genes such as caspase-3, caspase-7, caspase-8 and PARP [108]; increases p27Kip1 and p21Cip1/Waf1, and also increases the G0/G1 phase regulators which cause cell cycle arrest [108]; and suppresses cell migration and invasiveness through IGF-IR/MEK/ERK signaling pathway by targeting IGF-IR, MMP-2, MMP-7 and MMP-9 [108,110].