Moreover, miR-139-5p expression can be regulated by NOTCH1, the knock-down of NOTCH1 phenocopied the inhibitory effect of miR-139-5p on CRC metastasis [108,109], inhibited EMT and enhanced the chemotherapeutic sensitivity of CRC by downregulating BCL2 [111,112]. This evidence concerns the gene NOTCH1 and colorectal carcinoma.