Then we analyzed the anticancer activities of SCA, SCA-S1, and SCA-S2 against human lung carcinoma A-549 cells in terms of cell cycle, cytotoxicity, expression of caspase-3, mitochondrial membrane potential (MMP), cytochrome c release, Bcl-2 expression, Annexin V/ propidium iodide (PI) staining, and DNA fragmentation, as well as the underlying signaling transduction cascades. This evidence concerns the gene CASP3 and lung carcinoma.